|
|
| |
New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
 |
Try Goutezol for 60 Days
People Said About Goutezol Gout Remedy
| "I was only 30 when I got a gout attack. Goutezol really helped me to get over the attack in just two days and the ebook helps me with watching what I'm eating. My uncle have had gout problems too, so I recommended your product. Thanks a lot!" Matt, California |
 |
HOW PEGLOTICASE WORKS
What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS
Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
It has been having a decent degree of success.
Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
|
|
#1 Doctor Recommended Remedy
People Said About Goutezol Gout Treatment
| "week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago |
|
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.
SIDE EFFECTS
Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
|
|
|
|
| |
| |
|
|
|
|
|
|
| |
| |
Learn More about Natural Gout Remedy
Gout disease is most common in people between the ages of 30 and 50 years of age. The reason for this is that it takes a build up of about twenty years to cause a first gout attack. Uric acid levels will usually begin to increase at least that far ahead of the onset of gout. However, this does not rule out gout in people younger than 30 years old. Therefore, just because you're under 30, it... 
You may be experiencing gout symptom and you don't even know it. You may blame it on a number of other causes such as working conditions, not eating right, to name just a few of the excuses you come up with so you don't realize you may have a gout symptom.
Many people consider gout an old fashioned disease that has all but been eradicated. Not true, many people suffer daily from a gout...
What does pH stand for? Is it personal hygiene? Or proper health? Or possibly hydrated? Well no. It actually stands for the power of hydrogen. But without going deeper into biochemistry, gout sufferers just need to know that raising body pH levels makes the body more alkaline, and lowering them, more acidic.
Raising your body's pH levels is part of natural gout treatment. The theory is,...
Long known for their gorgeous bright red color, Tart Cherries are now found to be much, much more than simply a tart and delicious fruit.
The relief gout sufferers have noticed upon drinking Gout Cherry Juice has been recorded, and some have even been able to come off of all their medications because of the great changes. The pain associated with gout is a constant menace to those...
With the ever-rising cost of health care looming into the future, many of us are looking to the past for answers in natural home remedy (for Gout especially) for the treatment of what ails us.
This also goes for disorders like Arthritis and Gout. Home remedy is mostly being used as treatment.
Medicinal plants and herbs have been around for as long as humans have roamed the...
herbal supplement for gout | gout and how to prevent it | which foods contain purine | how to eliminate uric acid | cherry juice good for gout | what foods contain purines |
|
|
|
| |
| |
|
|
| |
|
|
|
|
